Alzheimer’s disease (AD) is a genetically heterogeneous, crippling neurodegenerative disorder, which is slow in onset but relentless in progress. The major symptoms of AD include dementia, aphasia, apraxia, agnosia, dyslexia and agraphia. Excessive deposits of extracellular β-amyloid (Aβ) plaques, intraneuronal fibrillary tangles and neuronal loss in certain brain areas constitute the three major hallmarks of AD. Diminished cholinergic transmission in brain, elevated total cholesterol levels and vitamin B group deficiency all appear to be the causative factors responsible for development of AD.
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