Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis

A number of clinical trials have addressed the impact of melatonin on solid tumors; as yet, however, there is no satisfactory synthesis of the data. We performed a systematic review and meta-analysis of the literature for all randomized controlled trials (RCTs) examining survival at 1 yr that involve the use of melatonin in the treatment of a variety of cancers.