The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction - an evaluation using primates, rabbit and rat

Abstract

Hormonal effects of Tribulus terrestris (TT) were evaluated in primates, rabbit and rat to identify its usefulness in the management of erectile dysfunction (ED). TT extract \Vas administered intravenously, as a bolus dose or 7.5. 15 and 30 mg kg. in primates for acute study. Rabbits and normal rats were treated with 2.5, 5 and 10 mg/kg of TT extract orally for 8 weeks, for chronic study. In addition, castrated rats were treated either with testosterone cypionate (10 mg/ kg, subcutaneously: biweekly for 8 weeks) or TT orally (5 mg/kg daily for 8 weeks). Blood samples were analyzed for testosterone (T), dihydrotestosterone (DHT) and dehydroepiandrosterone sulphate (DHEAS) levels using radioimmunoassay. In primates, the increases in T (52%), DHT (31 %) and DHEAS (29°%) at 7.5 mg/kg were statistically significant. In rabbits, both T and DHT were increased compared to control, however, only the increases in DHT (by 30% and 32% at 5 and 10 mg/kg) were statistically significant. In castrated rats increases in T levels by 51% and 25% were observed with T and TT extract respectively that were statistically significant. TT increase some of the sex hormones, possibly due to the preser1ce of protodioscin in the extract. TT may be useful in mild to moderate cases of ED.