The role of vitamin C in the prevention and treatment of the common cold has been a subject of controversy for at least 60 years. Public interest in the subject, stimulated originally by the vigorous advocacy of Nobel laureate Linus Pauling during the 1970s, continues to be high. We have recently updated the Cochrane Review on this topic (Text S1), incorporating 55 comparative studies that have been carried out over a period of 65 years.
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