Antifungal activity of Uncaria tomentosa (Willd.) D.C. against resistant non-albicans Candida isolates

This study investigated in vitro antifungal activity of the hydroethanolic extract (EXT), quinovic acid glycosides (QAPF), oxindole alkaloids (OAPF), water-soluble (WSF) and insoluble fractions of polyphenols (WIF) obtained from Uncaria tomentosa bark against non-albicans Candida resistant isolates. Cytotoxicity and genotoxicity of the major fractions were also assayed. Growth inhibition was assayed by the broth microdilution method according to the CLSI M27-A3 guideline. The most active fractions were evaluated regarding cell ultrastructure, sorbitol metabolism, and infrared (FT-IR) analysis of pseudomycelia of C. krusei, C. glabrata and C. parapsilosis. Fluconazole, terbinafine and anidulafungin were used as reference drugs