SAMENTO

The purpose of this study was to examine the effect of orally administered Uncaria tomentosa aqueous extracts (UTE) (Willd. ex Roem.&Schult.) DC. (Rubiaceae) during 7, 15, 30 and 90 days of treatment on the expression of anxiety, as expressed in the elevated plus maze test in male Albino Swiss mice.

Uncaria tomentosa(“una˜ de gato”; “cat’s claw”), a woody vine native to the Amazon rainforest,is commonly used in South American traditional medicine to treat a broad spectrum of diseases.Although recent studies have reported anti-inflammatory and anti-proliferative properties of different alkaloids extracted from this plant, the underlying molecular mechanisms of these effects have not been elucidated yet.

Silymarin and silybin are some of the major bioactive constituents of St Marys Thistle (Silybum marianum), displaying potent anti-inflammatory and antioxidative activity. These effects may be useful in reducing neurological injury induced by ischemic stroke.

Uncaria tomentosa (Willd. Ex Schult) DC is used by indigenous tribes in the Amazonian region of Central and South America to treat inflammation, allergies and asthma. The therapeutic properties of U. tomentosa have been attributed to the presence of tetracyclic and pentacyclic oxindole alkaloids and to phenolic acids.

This study was designed to determine the diversity and antibacterial activity of endophytic fungi isolated from Uncaria tomentosa. Leaf and stem were disinfected superficially and inoculated in PDA and SDA medium, with and without plant extract and incubated at 18 and 28°C for isolation of endophytic fungi.

Brain aging and Alzheimer’s disease both demonstrate the accumulation of beta-amyloid protein containing “plaques” and tau protein containing “tangles” that contribute to accelerated memory loss and cognitive decline. In the present investigation we identified a specific plant extract and its constituents as a potential alternative natural solution for preventing and reducing both brain “plaques and tangles”.

Uncaria tomentosa (Willd.) DC (Rubiaceae) is a vine that grows in the Amazon rainforest. Its bark decoctions are used by Peruvian Indians to treat several diseases. Chemically, it consists mainly of oxindole alkaloids.

Cat’s claw (Uncaria tomentosa and Uncaria guianesis) is a medicinalplant from the Amazon commonly used to treat disorders such as arthritis, gastritis and osteoarthritis. The mechanism of cat’s claw appears to be as an inhibitor of TNFa and antioxidant.

Samento (extract from Uncaria tomentosa) and Banderol (extract from Otoba parvifolia) have been demonstrated to have anti-inflammatory and antimicrobial properties, e.g., against different morphological forms of Borrelia burgdorferi. However, there is hardly any data on the pharmacological safety of these two herbal medicines.

To evaluate the effectiveness of Uncaria tomentosa in minimizing the side effects of chemotherapy and improving the antioxidant status of colorectal cancer (CRC) patients, a randomized clinical trial was conducted.

Previous studies in patients with advanced cancer have reported that Cat’s claw dry extract (Uncaria tomentosa) and Guarana (Paullinia cupana) showed beneficial effects in patients with terminal cancer. Our objective is to investigate the combined action of these extracts in the control of symptoms in these patients.

The previous study was to investigate the anti-cancer activity of aqueous extracts from Inonotus obliquus (IO), Cordyceps militaris (CM) and Uncaria tomentosa (UT). The antioxidant and immunomodulatory activities of aqueous extracts were measured and compared.

Breast cancer is the most frequent neoplasm affecting women worldwide. Some of the recommended treatments involve chemotherapy whose toxic effects include leukopenia and neutropenia. This study assessed the effectiveness of Uncaria tomentosa (Ut) in reducing the adverse effects of chemotherapy through a randomized clinical trial.

Uncaria tomentosa constitutes an important source of secondary metabolites with diverse biological activities mainly attributed until recently to alkaloids and triterpenes. We have previously reported for the first-time the polyphenolic profile of extracts from U. tomentosa, using a multi-step process involving organic solvents, as well as their antioxidant capacity, antimicrobial activity on aerial bacteria, and cytotoxicity on cancer cell lines.

Uncaria tomentosa is considered a medicinal plant used over centuries by the peruvian population as an alternative treatment for several diseases. Many microorganisms usually inhabit the human oral cavity and under certain conditions can become etiologic agents of diseases.

Uncaria tomentosa, commonly known as cat’s claw, is a medicinal plant native to Peru, which has been used for decades in the treatment of various inflammatory disorders. Uncaria tomentosa can be used as an antioxidant, has anti-apoptotic properties, and can enhance DNA repair, however it is best know for its anti-inflammatory properties.

Cat’s claw is an herbal medicine from the Amazon that is used widely to treat inflammatory disorders. The purpose of this study was to characterize the antioxidative and antiinflammatory properties of cat’s claw, Uncaria tomentosa (UT) and Uncaria guianensis (UG)

Uncaria tomentosa (Willd.) DC. (Rubiaceae), commonly known as ‘Cat’s claw’ or ‘un˜a de gato’, is a vine that grows in the Amazon rainforest. In Peru, its bark has been traditionally used for the treatment of many ailments, such as viral infections, cancer, gastric illnesses (gastric ulcers), arthritis and other inflammatory disorders (Reinhard, 1997).

In this study, we demonstrated that Uncaria tomentosa extract (UTE) protects mice from a lethal dose of Listeria monocytogenes when administered prophylactically at 50, 100, 150 and 200 mg/kg for 7 days, with survival rates up to 35%. These doses also prevented the myelosuppression and the splenomegaly caused by a sublethal infection with L. monocytogenes, due to increased numbers of granulocyte-macrophage progenitors (CFU-GM) in the bone marrow.

We investigated the effect of the crude herbal extract from Uncaria tomentosa (UT) on non-alcoholic fatty liver disease (NAFLD) in two models of obesity: high fat diet (HFD) and genetically obese (ob/ob) mice.

We investigated the effect of the herbal extract Uncaria tomentosa (Ut) (50 mg/kg, crude extract, for 5 consecutive days) in two mice models of obesity: high fat diet (DIO) fed mice and the genetic ob/ob mice.

Type 1 diabetes (T1D), which resulting in hyperglycemia, is an autoimmune disease. This disease characterized by destruction of the insulin-secreting cells of the islets of Langerhans. The CD4 T regulatory cells (Tregs) are important for prevention of disease. Treg cells (defined as CD4+CD25+Foxp3+) have been found to play a critical role in maintaining self-tolerance and preventing autoimmune diseases.

Uncaria tomentosa (Willd.) DC. (Rubiaceae) (Ut), also known as cat's claw, is a woody liana widely spread throughout the Amazon rainforest of Central and South America, containing many chemical constituents such as oxindole alkaloids, which are responsible for various biological activities.

Type 1 diabetes (T1D), which resulting in hyperglycemia, is an autoimmune disease. This disease characterized by destruction of the insulin-secreting cells of the islets of Langerhans. The CD4 T regulatory cells (Tregs) are important for prevention of disease.

The genus Uncaria belongs to the family Rubiaceae, which mainly distributed in tropical regions, such as Southeast Asia, Africa and Southeast America. Their leaves and hooks have long been thought to have healing powers and are already being tested as a treatment for asthma, cancer, cirrhosis, diabetes, hypertension, stroke and rheumatism. The present review aims to provide systematically reorganized information on the ethnopharmacology, phytochemistry and pharmacology of the genus Uncaria to support for further therapeutic potential of this genus.

Traditionally used medicinal plants, herbs and spices in Latin America were investigated to determine their phenolic profiles, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension.

We investigated the effect of the crude herbal extract from Uncaria tomentosa (UT) on non-alcoholic fatty liver disease (NAFLD) in two models of obesity: high fat diet (HFD) and genetically obese (ob/ob) mice. Both obese mouse models were insulin resistant and exhibited an abundance of lipid droplets in the hepatocytes and inflammatory cell infiltration in the liver, while only the HFD group had collagen deposition in the perivascular space of the liver.

Traditional Chinese medication (TCM) is increasingly used to treat cardiovascular disease (CVD) in China and some other Asian countries. However, therapeutic efficacy and adverse effects of TCM are difficult to evaluate because few large-scale, randomized controlled trials (RCTs) enrolling patients with CVD have been performed. In this Review, we critically examine the current evidence on the cardiovascular effects of TCM.

Populations in Africa mostly rely on herbal concoctions for their primarily health care, but so far scientific studies supporting the use of plants in traditional medicine remain poor. The present study was undertaken to evaluate the anti-hyperglycemic effects of Picralima nitida (seeds), Nauclea latifolia (root and stem) and Oxytenanthera abyssinica (leaves) commonly used, in diabetic pregnancy.

We investigated the effect of the herbal extract Uncaria tomentosa (Ut) (50 mg/kg, crude extract, for 5 consecutive days) in two mice models of obesity: high fat diet (DIO) fed mice and the genetic ob/ob mice. Both obese mice exhibited diabetes (151±4 mg*dL-1 vs. 90±2 mg*dL-1 and 205±15 mg/dL vs. 163±11 mg/dL, p<0.05, respectively) and insulin resistance (Kitt: 4.0±0.1%*min-1 vs. 0.5±0.3%*min-1, p<0.05, respectively).

The effects of fipronil (FPN) on the liver of rats were studied. Rats (n = 6) were treated with 9.7 mg/kg (1/10 of FPN LD50), and other rats (n = 6) received 120 mg/kg of 10% Uncaria tomentosa extract, while a mixture of 9.7 mg/kg FPN and 120 mg/kg of 10% Uncaria tomentosa extract were administered orally to the rats (n = 6) daily for 6 weeks. Body, hepatic weights, liver enzymes, and lipid profile were determined.

This contribution presents 82 species of medicinal plants whose products are sold and consumed as cholesterol lowering in the Buenos Aires-La Plata conurbation, Argentina. The hypocholesterolemic effect is relevant because the high level of blood cholesterol is one of the major risk factors for cardiovascular diseases, leading causes of death and disability almost worldwide.

Diabetes mellitus is a disease associated with dysfunction of pancreatic β-cells and oxidative stress. A treatment which can reduce theimpact of oxidative stress may be beneficial in the treatment of diabetes. Therefore, this study aimed to investigate the effect of gambier extract on the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and blood glucose level (BGL) in type 2 diabetes mellitus (T2DM).

Diabetes mellitus is a disease associated with dysfunction of pancreatic β-cells and oxidative stress. A treatment which can reduce the impact of oxidative stress may be beneficial in the treatment of diabetes. Therefore, this study aimed to investigate the effect of gambier extract on the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and blood glucose level (BGL) in type 2 diabetes mellitus (T2DM).‍

Recently, Uncaria tomentosa (Willd.) D.C. has become known as a healing plant with an eth­nomedicinal background. There have been several reports on its constituents, in particular, oxindole alkaloids. It was found that 2 chemotypes of Uncaria tomentosa with different al­kaloid patterns occur in nature.

An informal study conducted by the American Lyme Disease Alliance (ALDA), found that most patients diagnosed with Chronic Fatigue Syndrome (CFS) were actually suffering from Lyme disease. Out of a group of CFS 31 patients, 28 were found to be ill as a result of Lyme.

Many people think of Lyme disease as a simple illness caused by the bite of an infected tick.Though a bite may be a triggering event, this perspective is simplistic and does not take into consideration the numerous issues that both the patient and doctor must consider and treat in order to attain the best possible outcomes. Furthermore, medical literature suggests that Lyme disease is a complex illness which may be transmitted by mosquito bites, blood transfusions, sexual intercourse and many other ways.

From an early age, I had a great interest in medicine. When I was young, I thought I wanted to be a brain surgeon. Later, in medical school at the University of Turku, Finland, everything interested me. I was also lucky enough to study a course on acupuncture, something that is not normally taught in Finnish medical schools.

Despite the widespread belief that no remedy can treat more than a couple of diseases, the truth is entirely different. Even in conventional medicamental medicine, there are drugs -for instance corticosteroids or non-steroidal anti-inflammatory drugs - that do treat or positively influence a large number of "diseases" or clinical symptoms. Additionally many antibiotics, in spite of their apparent or relative specificity, successfully treat quite a large number of different bacterial infections.

The remedy SAMENTO has an exceptionally broad spectrum of therapeutic effect in different types of internal, endocrine, dermatological, neurological, oncological, immunodeficiency and many other diseases. A clinical study was carried out at LECHITEL Medical Center on 24 patients diagnosed with “Dystonia neurovegetativa”.

Use of cat’s claw might be beneficial in patients with advanced cancer by improving their quality of life and reducing fatigue. The mechanism of action does not seem to be related to the anti-inflammatory properties of this plant.

UT hydroalcoholic extract successfully reduced the tumor growth. In addition, treatment with UT reduced the activity of AST, which had been increased as a result of tumor inoculation, thus attempting to return it to normal levels. UT did not reverse the increase of LDH and GGT plasma levels, although all doses were remarkably effective in reducing urea plasma levels.

This is a report on the efficacy of tetracyclic oxindole free Uncaria Tomentosa, commonly known as TOA-free Cat’s Claw or Una de Gato which is distributed under the brand-name Samento. This research has been performed and published by NuLife Sciences, Inc. based on clinical observations which were recorded as photocomparative studies of observations on the Native blood in conjunction with a coagulation screening methodology known as the Oxidative Stress Test (Dried Blood Evaluation Screen).

Medullary thyroid carcinoma (MTC), a rare calcitonin-producing tumor, is derived from parafollicular Ccells of the thyroid and is characterized by constitutive Bcl2 overexpression. The tumor is relatively insensitive to radiation therapy as well as conventional chemotherapy. To date, the only curative treatment is the early and complete surgical removal of all neoplastic tissue.

Uncaria tomentosa (Willd.) DC. (Rubiacee), also known as uña de gato, is a plant that grows wild in the upper Amazon region of Peru and has been widely used in folk medicine to treat several health conditions including cancer. We have produced an aqueous extract from Uncaria tomentosa (UT-ex) and analyzed its effects on squamous carcinoma cells and immortalized HaCaT keratinocytes.

Lyme disease was first recognized around 1975, when a mysterious outbreak of juvenile rheumatoid arthritis occurred around Lyme, Connecticut. In 1982, the causative agent of Lyme disease was discovered by Willy Burgdorfer. It turned out to be a spirochete (spiral-shaped bacterium) from the genus Borrelia, subsequently named Borrelia burgdorferi (Bb).

Samento: pentacyclic chemotype (TOA free) of Uncaria tomentosa. The same botanical species that appears in other forms (composition of different secondary metabolites) due to different growing conditions 2 • Pentacyclic oxindole alkaloids (POA) • Tetracyclic oxindole alkaloids(TOA) Inhibits NF-B, and the production of TNF-, inhibits proliferation of human lymphoblasts and promotes phagocytosis Antagonistic effects on POA, decreasing its effect.

Recent advances in the chemical analysis of Cat's Claw have shed new light on its use as a natural therapeutic agent. Specifically, it has been found that the clinical efficacy increases as the pentacyclic oxindole alkaloid (POA) fraction increases and as the tetracyclic oxindole alkaloid (TOA) content decreases respectively. Samento ( Uncaria tomentosa) is a rare form of Cat's Claw that has been found to be 100 per cent TOA free.

Samento will be used in humans because of the vital importance of carrying out these first-step tests. They will not only guarantee the quality of the product, but will also establish that there are no adverse side effects in humans who take the product. As discussed in numerous international works, the study of acute toxicity is indispensable, and guarantees (within the margin of error associated with the technique) that the potential for toxicity from the compounds that will be ingested or that may enter into the system accidentally will be learned.

The auricular edema is achieved by applying 12-0- Tetradecanoil Forbol-13 Acetate (TPA), one of the components responsible for the irritating action of croton oil, into the auditory pavilion of the mouse. The inflammatory reaction consists of erythema, edema and infiltration by polymorphonuclear leukocytes. As such, eicosanoid -type mediators are freed, inducing degranulation of the mast cell. This technique thus allows the evaluation of the inhibiting substances of the biosynthesis of prostaglandins and leukotrienes.

Twenty-four weeks of treatment with the UT extract resulted in a reduction of the number of painful joints compared to placebo (by 53.2% vs. 24.1%; p=0.044). Patients receiving the UT extract only during the second phase experienced a reduction in the number of painful (p=0.003) and swollen joints (p=0.007) and the Ritchie Index (p=0.004) compared to the values after 24 weeks of placebo. Only minor effects were observed.

I am in charge of the largest phytotherapy clinic in Scotland and give lectures in the United States on weight control, nutrition and diabetes prevention. The aim of my visit here is not to share with you my clinical experience with Cat’s Claw but to help you understand how it works.

The pictures on the following pages indicate the power and benefits of Samento. The "Before Treatment" photographs are of damaged blood cells due to free radical attack. The "After Treatment" photographs show cells after treatment with only Samento. Note how the attack of free radicals has damaged the cells. The formerly healthy cells have lost their integrity.

The purpose of this investigation was to evaluate the ability of cat’s claw, an Amazonian medicinal plant, to treat osteoarthritis of the knee, collect safety and tolerance information and compare the antioxidant, and anti-inflammatory actions of Uncaria guianensis and Uncaria tomentosa in vitro.

Lyme Disease – The most common vector-borne infectious disease in the Northern United States. Number of people diagnosed with Lyme Disease each year in the US ≈300,000. Rapidly spreading throughout Europe and northeast Asia (The Centers for Disease Control and Prevention). New discoveries of ticks fossilized in amber show that the bacteria which cause it may have been lurking around for 15 million years.

In a six-month prospective cohort study designed to compare the effectiveness of an alternative method of Lyme borreliosis treatment to conventional antibiotic treatment, patients receiving alternative treatment showed greater improvement based on self-reported disease symptoms, physician evaluation and clinical laboratory tests. The alternative treatment consisted of the use of Pentacyclic Alkaloid Chemotype Uncaria tomentosa, or TOA-Free Cat’s Claw, dietary and lifestyle changes, enzymes, vitamins, minerals, detoxification herbs and body pH-balancing. Conventional treatment included antibiotic treatment as recommended by the American Medical Association.

A tick-borne, multisystemic disease, Lyme borreliosis caused by the spirochete Borrelia burgdorferi has grown into a major public health problem during the last 10 years. The primary treatment for chronic Lyme disease is administration of various antibiotics. However, relapse often occurs when antibiotic treatment is discontinued. One possible explanation for this is that B. burgdorferi become resistant to antibiotic treatment, by converting from their vegetative spirochete form into different round bodies and/or into biofilmlike colonies.

The woody Amazonian vine Uncaria tomentosa (cat’s claw) has been recently more and more popular all over the world as an immunomodulatory, antiinflammatory and anti-cancer remedy. This study investigates anti-proliferative potency of several cat’s claw preparations with different quantitative and qualitative alkaloid contents on HL-60 acute promyelocytic human cells by applying trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay (MTT).

Uncaria tomentosa (Willd.) DC (Rubiaceae) is a large woody vine that is native to the Amazon and Central American rainforests and is used widely in traditional medicine for its immunomodulatory and antiinflammatory activities. The present work used in vivo immunotoxic and in vitro immunomodulatory experiments to investigate the effects of a pentacyclic oxindole alkaloid extract from U. tomentosa bark on lymphocyte phenotype, Th1/Th2 cytokine production, cellular proliferation and cytotoxicity.

Objetives: This study aimed to research the in vitro immunomodulatory effects of an Uncaria tomentosa hydroalcoholic extract standardized (5.03%, pentacyclic oxindole alkaloids) (UT-POA) on the immunophenotype of dendritic cells (DC) subsets, Th1, Th2, Th17 and IL-12 cytokines from patients with stage II breast cancer (BCII) and healthy women (H). Materials and methods. Blood of 11 H and 7 BCII was obtained, PBMC were isolated and cultured for 2h with/without various concentrations of UT-POA and stimulated or not with LPS for 24h. PBMC were labeled with specific antibodies for DC and in the supernatant we measured Th1/Th2/Th17 cytokines, both by flow cytometry. Furthermore IL-12 was measured by ELISA.

Ethnopharmacological relevance: Uncaria tomentosa (Willdenow ex Roemer & Schultes) DC. (Rubiaceae) is a Peruvian thorny liana, commonly known as “cat's claw”, and traditionally used in folk medicine to deal with several inflammatory diseases. Mitraphylline (MTP) is the most abundant pentacyclic oxindolic alkaloid (POA) from U. Tomentosa and has been reported to modify the inflammatory response.

Objectives: To evaluate the immunomodulatory effect on lymphocyte subsets, dendritic cells (DC), Th1 / Th2 / Th17 and inflammatory cytokines on systemic level and/or in the tumor microenvironment of mice with or without melanoma. Materials and methods: Peripheral blood and/or primary tumors samples were obtained of mice with B16 melanoma treated or not with a hydroalcoholic extract of Uncaria tomentosa (UT) with 5.03% of pentacyclic oxindole alkaloids (UT-POA) obtained from the bark of the plant. All cell assays and cytokine measurements were performed by flow cytometry.

Ethnopharmacological relevance: Uncaria tomentosa (Willd.) DC (Rubiaceae)is a species native to the Amazon rainforest and surrounding tropical areas that is endowed with immunomodulatory properties and widely used around the world. In this study we investigated the immunomodulatory potential of Uncaria tomentosa (UT) aqueous–ethanol extract on the progression of immune-mediated diabetes.

Uncaria tomentosa have been used to treat viral diseases such as herpes due to multiple pharmacological effects, but its therapeutic efficacy against this virus have not been reported yet. Thus, in vitro antiherpetic activity of hydroethanolic extract from barks, purified fractions of quinovic acid glycosides and oxindole alkaloids was evaluated by plaque reduction assay, including mechanistic studies (virucidal, attachment and penetration action).

Experimental endometriosis was induced in twenty-five female Wistar rats. After three weeks, 24 animals developed grade III experimental endometriosis and were divided into two groups. Group ‘‘U’’ received U. tomentosa extract orally (32 mg/day), and group ‘‘C’’ (control group) received a 0.9% sodium chloride solution orally (1 ml/100 g of body weight/day). Both groups were treated with gavage for 14 days.

The objective of this study is to report the clinical use of 2% Uncaria tomentosa gel against denture stomatitis (DS) as an alternative treatment. The patient was a 65-year-old, denture-wearing woman. At the clinical examination, her palate showed hyperplasic and erythematous mucosa indicating DS type II. DS is a chronic oral disease that affects denture wearers. It occurs as an inflammatory reaction in denturewearing patients under maxillary prostheses.

Uncaria tomentosa (Willd.) DC., a large woody vine native to the Amazon and Central American rainforests has been used medicinally by indigenous peoples since ancient times and has scientifically proven immunomodulating, anti-inflammatory, cytotoxic and antioxidant activities. Several inflammatory mediators that are implicated in vascular permeability and shock are produced after Dengue Virus (DENV) infection by monocytes, the primary targets for virus replication.

Cat’s claw (Uncaria tomentosa) is a medicinal plant from the Amazon River basin that is widely used for inflammatory disorders and was previously described as an inhibitor of NF-kB. Cat’s claw was prepared as a decoction (water extraction) of micropulverized bark with and without concentration by freeze-drying. Murine macrophages (RAW 264.7 cells) were used in cytotoxicity assays (trypan blue exclusion) in response to the free radical 1,1-diphenyl2-picrilhydrazyl (DPPH, 0.3 mM) and ultraviolet light (UV) light.

Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been used to prevent the occurrence of HE, although this compound is not effective in established lesions.

Pteropodine and isopteropodine are heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC, a Peruvian medicinal plant known as cat’s claw. In this study, the effects of these alkaloids on the function of Ca2+ -activated Cl
currents evoked by stimulation of G protein-coupled muscarinic M1 acetylcholine and 5-HT2 receptors were studied in Xenopus oocytes in which rat cortex total RNA was translated.

Uncaria tomentosa (Willd. ex Schult.) DC (Rubiaceae), known as Cat’s Claw or Uña de gato, is a traditionally used medicinal plant native to Peru. Some studies have shown that U. tomentosa can act as an antiapoptotic agent and enhance DNA repair in chemotherapy‑treated cells although others have shown that U. tomentosa enhanced apoptosis.

Ethnopharmacological relevance: The Asháninkas, indigenous people of Peru, use cat’s claw (Uncaria tomentosa) to restore health. Uncaria tomentosa has antioxidant activity and works as an agent to repair DNA damage. It causes different effects on cell proliferation depending on the cell type involved; specifically, it can stimulate the proliferation of myeloid progenitors and cause apoptosis of neoplastic cells.

Preparations from Uncaria tomentosa, a South American Rubiaceae, have been used in the Peruvian traditional medicine for the treatment of infective, inflammatory and tumoral processes. In this study, the pentacyclic oxindole alkaloid mitraphylline was isolated from the dried inner bark of this plant species, and its structure elucidated by analysis of NMR spectroscopic data.

Uncaria tomentosa inner bark extract is a popular plant remedy used in folk medicine to treat tumor and inflammatory processes. In this study, the anti-tumoral effects of its pentacyclic alkaloid mitraphylline were investigated. Furthermore, its growth-inhibitory and cytotoxic effects on glioma GAMG and neuroblastoma SKN­BE(2) cell lines were studied using cyclophosphamide and vincristine as controls.

Bladder cancer is the second most prevalent malignancy in the genitourinary tract and remains a therapeutic challenge. In the search for new treatments, researchers have attempted to find compounds with low toxicity. With this goal in mind, Uncaria tomentosa is noteworthy because the bark and root of this species are widely used in traditional medicine and in adjuvant therapy for the treatment of numerous diseases.

Pteropodine is a heterohimbine-type oxindole alkaloid specifically isolated from ‘Cat’s claw’ (Uncaria tomentosa), a plant that has shown cytostatic, anti-inflammatory and antimutagenic properties and is used in traditional medicine to cure a number of diseases. In this report, we studied the ability of pteropodine to decrease the rate of sister-chromatid exchanges and micronucleated polychromatic erythrocytes in mice administered doxorubicin.

Medicinal plants have long been used in traditional medicine for therapeutic purposes and their healing effects have well been recognized since ancient times. Geranium robertianum L. and Uncaria tomentosa (Willd.) DC. are medicinal plants with many therapeutic applications, being used in the treatment of antiinflammatory and anti-cancer diseases. G. robertianum L. belongs to the family of Geraniacea and is native from central and meridian Europe and Asia.

Uncaria tomentosa (Willd) D. C. (Rubiaceae) known as cat’s claw is a plant widely used in traditional Peruvian medicine to treat cancer and chemotherapy side effects among a wide range of other diseases (Obrego´n-Vilches, 1995). Research on this matter led to the discovery of pentacyclic monoterpenoid oxindole alkaloids (MOA) with immunomodulatory, cytotoxic, anti-AIDS, and anti-leukemic activities.

The effect of ethanolic and aqueous extracts from leaves and bark of Uncaria tomentosa was studied, with particular attention to catalase activity (CAT – EC. 1.11.1.6). We observed that all tested extracts, at a concentration of 250 lg/mL were not toxic to erythrocyte catalase because they did not decreased its activity. Additionally, we investigated the protective effect of extracts on changes in CAT activity in the erythrocytes incubated with sodium salt of 2,4-dichlorophenoxyacetic acid (2,4-D-Na) and its metabolites i.e., 2,4-dichlorophenol (2,4-DCP) and catechol.

Ozone (O3) inhalation has been associated with respiratory tract inflammation and lung functional alterations. To characterize the O3-induced lung inflammation in mice, the effective dose and exposure time were determined. Total protein levels of bronchoalveolar lavage fluid (BALF), cytological smears, and lung histopathology and morphometry were used to assess and measure the degree of pulmonary inflammation in the mouse model.

This study aimed to compare the anti-neoplastic effects of an Uncaria tomentosa (UT) brute hydroethanolic (BHE) extract with those of two fractions derived from it. These fractions are choroformic (CHCl3) and n-butanolic (BuOH), rich in pentacyclic oxindole alkaloids (POA) and antioxidant substances, respectively.

Endodontic therapy aims to remove diseased tissue, eliminate bacteria present in the canals and dentinal tubules, and prevent recontamination after treatment. These objectives are achieved by biomechanical cleaning and shaping of the root canal system, by sealing root canals with a 3-dimensional obturation, and by placing a coronal seal. Unfortunately, because of the anatomical complexity of the root canal system, organic and inorganic residues and bacteria cannot be completely removed and often persist.

Candida species are harmless saprophyte yeasts, a normal component of the human biota in the gastrointestinal tract and oral and vaginal mucosae. These yeasts can cause superficial infections manifested as thrush and vaginitis; excepting in immunecompromised and immune-suppressed patients, for instance, to whom they can cause severe systemic infections.

This study investigated in vitro antifungal activity of the hydroethanolic extract (EXT), quinovic acid glycosides (QAPF), oxindole alkaloids (OAPF), water-soluble (WSF) and insoluble fractions of polyphenols (WIF) obtained from Uncaria tomentosa bark against non-albicans Candida resistant isolates.

The influence of water extract of Uncaria tomentosa (Willd.) DC. bark on Pseudomonas aeruginosa infection was studied. The preparation was obtained by extraction of bark Uncaria tomentosa with water (37°C, 24 h) and further fractionation. Inbred C57BL/6 mice 7-9 weeks old, ca 20 g of body mass, females, were fed water extract for 7 days (10, 20 or 100 mg/kg), or water (controls).

Mitraphylline (MTP) is the major pentacyclic oxindolic alkaloid presented in Uncaria tomen­tosa. It has traditionally been used to treat disorders including arthritis, heart disease, cancer, and other inflammatory diseases. However, the specific role of MTP is still not clear, with more comprehensive stud­ies, our understanding of this ancient herbal medicine will continue growing.

Decoctions prepared from the bark of Uncaria tomentosa (cat
s claw) are widely used in the traditional Peruvian medicine for the treatment of several diseases, in particular as a potent anti-inflammatory agent. Therefore, the main purpose of this study was to determine if the well-known anti-inflammatory activity of cat
s claw decoction was related with its reactivity with the oxidant species generated in the inflammatory process and to establish a relationship between such antioxidant ability and its phenolic composition.

Uncaria tomentosa (Willd. ex Roem. & Schult.) DC. (Rubiaceae) is widely used by populations living in South America to treat many ailments associated with inflammatory disorders. Mitraphylline was shown to be the major pentacyclic oxindolic alkaloid present in the bark chloroformic extract of this plant. Its activity against cytokines involved in inflammation process was tested in a murine model in vivo.