The antitumor effect of Samento, pentacyclic chemotype of Uncaria tomentosa, is probably due to its anti-inflammatory activity

Samento: pentacyclic chemotype (TOA free) of Uncaria tomentosa. The same botanical species that appears in other forms (composition of different secondary metabolites) due to different growing conditions 2 • Pentacyclic oxindole alkaloids (POA) • Tetracyclic oxindole alkaloids(TOA) Inhibits NF-B, and the production of TNF-, inhibits proliferation of human lymphoblasts and promotes phagocytosis Antagonistic effects on POA, decreasing its effect.

Objective: Evaluate the anti-inflammatory and anti-tumour effects of Samento (pentacyclic chemotype of Uncaria tomentosa)