Eschscholtzia californica Cham. and Valeriana officinalis L. have long been used for the management of sleep disorders and anxiety. Use of a fixed combination of these two plant extracts (Phytostandard® d’Eschscholtzia et de Valeriane, PiLeJe Laboratoire, France) was investigated in an observational study.

The aim of this three-week, double-blind, placebo-controlled pilot study was to determine the efficacy of homeopathic Valeriana officinalis mother tincture (MT) and 3X potency on attention deficit hyperactivity disorder (ADHD).

To evaluate in vivo the association of hypericum (Hypericum perforatum), valerian (Valeriana officinalis) and kava (Piper methysticum) with analgesia by assessing their effects in reducing orofacial pain as well as the possible hepatic, hematologic and biochemical alterations induced by regular administration of these extracts.

Chamomile is most popular used medicinal plant and extensively consumed as a tea or tisanes. Traditionally this plant was used for treatment of many ailments such as allergy disorders and inflammatory mediated diseases.

Valeriana officinalis L. (valerian) root extract has been used as an antiepileptic herbal medicine in Iran. Aim of this study: In the present study the effect of valerian extracts on an experimental model of temporal lobe epilepsy (TLE) was evaluated. Moreover, the involvement of adenosine system in the actions of aqueous extract of valerian was evaluated.

In recent years, large number of preclinical and clinical studies support the hypothesis of a link between oxidative stress, anxiety and depression. In search of novel sources of antioxidants in the last years, medicinal plants traditionally used in folk medicine have been extensively studied for their antioxidant activity (AOA).

This work investigated the effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. (EPV) in rats under going elevated plus maze (EPM) and open-field test (OFT).

In traditional herbal folklore a number of plants are reputed to have sedative properties. The list includes almonds, camomile, catmint, fennel, hops, indian hemp, lettuce, lime, marjolaine, may blossom, melissa, mullein, oats, orange flower, passion flower, poppy seed, rosemary, willow and valerian.

The objective of the present study was to evaluate the effectiveness of an herbal drug (valerian) to control anxiety during mandibular third molar extraction compared with a reference benzodiazepine drug commonly used in dental procedures (midazolam).

We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity.

The current study explores data from a 2009 clinical chamomile trial in humans to determine if chamomile provides clinically meaningful antidepressant activity versus a placebo.

Patients with bipolar disorder frequently continue to experience residual anxiety and insomnia between mood episodes. In real-world practice, patients increasingly self-prescribe alternative medicines.

Sleep disturbance is one of the symptoms of menopause, which occurs due to a decrease in sex hormones and dramatically affects the quality of life. This study was designed to compare the effects of relaxation and Valerian on insomnia of menopause women.

Anxiety is the most common psychiatric disorder which can be cured by herbal and chemical medicine. Herbal medicine and complementary medicine are widely used among people suffering from anxiety disorder

Anxiety can hamper wound healing and tissue repair, and spending inordinate mental and physical energy during prolonged stress can cause hospitalization and delayed discharge.

Parkinson’s disease (PD) is one of the most important neurodegenerative worldwide disorders. The potential cytoprotective effects of aqueous extract of Valeriana officinalis on rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells were demonstrated.

To investigate the effects of Valeriana officinalis extract on behaviors, 5-hydroxytryptamine level and cell proliferation at cerebral hippocampus of a depressive rat model induced by chronic mild stress. Seventy male Sprague-Dawley rats were divided into 7 groups (10 per group) including normal control group, untreated depressive rat model group, negative control group , positive control group, low dosage Valeriana officinalis extract group,medium dosage Valeriana officinalis extract group and high dosage Valeriana officinalis extract group.

As discussed in numerous international works, the pharmacological study of the above-mentioned effect is indispensable, and guarantees (within the margin of error associated with the technique) that the potential for producing sedative effects in humans will be learned.

Extracts of Valeriana officinalis L. s.l. are used for treating mild sleep disorders and nervous tension. Despite intensive research efforts, the pharmacological actions accounting for the clinical efficacy of valerian remain unclear.

The Oxford dictionary defines serendipity as “the faculty of making happy and unexpected discoveries by accident”. During human history, the combination of serendipity and advances in biochemistry fostered the discovery of medicines from bio-sourced materials.

In the present study, the protective effect of V. officinalis on lipid peroxidation (LPO) induced by different pro-oxidant agents with neuropathological importance was examined.

There is an increasing interest in the health risks relatedto the use of herbal remedies. Although most consumers think thatphytomedicines are safe and without side effects, interactions betweencomplementary alternative and conventional medicines are being described.

Valeriana officinalis (Valerianaceae) has been of great interest for its therapeutic uses for treating mild nervous tension and temporary sleeping problems. In traditional European medicine it has been also reported as an antiinflammatory remedy.

The aim of the present study was to find out whether neuropharmacological effects in mice would be exerted by fresh valerian root extracts and some of its isolated fractions.

Valerian (Valeriana officinalis) belonging to valerianaceae family is a well known herb and medicinal plant that has been widely used all over the world especially in Europe, China and Middle East.

The present review describes the morphological, phytochemical and pharmacology aspects of Valeriana officinalis (Valerianaceae). Valeriana officinalis is a hardy perennial flowering plant. Valerian is native to Europe and Asia and has naturalized in eastern North America.

Stress is the psycho physiological sign which is really very complicate to describe. The following medicinal plants such as Caryophyllus Aromaticus, Valerian, Camellia sinensis, Rauvolfia Serpentine, Cinnamomum verum, Brahmi, are claimed as anti-stress, anti-aging, disease prevention and life strengthening activities found in scientific research articles.

This study investigated the relaxing effects of Valeriana officinalis L. (Valerianaceae) on human uterine muscle. The major uses of this species in Europe are as a sedative and an anxiolytic; it is also used as a spasmolytic to treat gastrointestinal spasm.

We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S ( – ) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleepinducing properties of HN.

Valeriana officinalis L. root extracts are traditionally taken for their sedative and anxiolytic properties and are also used for muscle relaxation. Relaxant effects were clearly observed on smooth muscle whereas data on effects on skeletal muscle are scarce and inconsistent.

This test was performed with the intention of determining the Acute Toxicity by oral intake of the product to be evaluated, given that this is one of the ways proposed for human intake.

Patients with coronary artery disease (CAD) experience different levels of anxiety during their hospital stay. Untreated anxiety among these patients can increase the risk of further cardiac events. The current study aimed at comparing the effects of lavender, valerian, and oxazepam on anxiety among hospitalized patients with CAD.

Disordered sleep has been found to be common in cancer survivors and contributes to fatigue and impaired overall functioning. The true prevalence and incidence of sleep disorders in the oncology population is not well documented, though reports range from 23%–61%.

Premenstrual syndrome (PMS) is a common disorder. Due to the knowledge lack of the precise etiology of this syndrome, different treatment methods are recommended, one of them is the use of medicinal herbs.

Sleep disturbances are common problems in patients with chronic heart failure (CHF) and are a significant contributing factor to fatigue and poor quality of life. The aim of the present study was to evaluate the effectiveness of Valeriana officinalis on sleep disturbance in patients with CHF

Extract of Valeriana officinalis have been used in folkloric medicine for its sedative, hypnotic, tranquilizer and anticonvulsant effects, and may interact with γ-aminobutyric acid (GABA) and/or benzodiazepine sites.

Neuroimmune factors have been considered as contributors to the pathogenesis of depression. Beside other therapeutic effects, Valeriana officinalis L., have been suggested to have anti-inflammatory effects. In the present study, the effects of V. officinalis L. hydro alcoholic extract was investigated on depression like behavior in ovalbumin sensitized rats.

Anxiety and depression are complex heterogeneous psychiatric disorders and leading causes of disability worldwide. This review summarizes reports on the fundamentals, prevalence, diagnosis, neurobiology, advancement in treatment of these diseases and pre clinical assessment of botanicals.

Anxiety is a natural feeling in people and every person experiences in certain conditions in his/her life. Anxiety refers to an unpleasant and vague feeling accompanied by worry about known and unknown origin.

Valerian root is the most commonly used herbal supplement for sedation and anxiolysis, but it is unknown whether it may affect functional brain connectivity. Our goal was to use electroencephalography (EEG) to investigate whether valerian root extract (VRE) affects resting‐state connectivity changes and whether such changes are associated with clinical symptoms. T

In this study, we investigated the potential protective effects of Valeriana officinalis (V. officinalis) against the toxicity induced by rotenone in Drosophila melanogaster (D. melanogaster).

Chronic treatment with classical neuroleptics in humans can produce a serious side effect, known as tardive dyskinesia (TD). Here, we examined the effects of V. officinalis, a medicinal herb widely used as calming and sleep-promoting, in an animal model of orofacial dyskinesia (OD) induced by long-term treatment with haloperidol.

Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement, primarily used to treat insomnia and anxiety. Until recently, its mechanism of action has remained unknown.