CHANCA PIEDRA

Endophytic fungi Chaetomium sp isolated from Phyllanthus niruri Linn. Mycelium powder was extracted by using ethyl acetate. Extract was fractionated using n-hexane, dichloromethane and ethanol 96%.

Solanum nigrum and Phyllanthus niruri are common herbs which are indigeneous to India. Solanum nigrum commonly called ‘manathakkali Keerai’ in Tamil, forms an indispensable part of South Indian diet.

Phylanthus niruri has been used to treat ailments related to the urogenital organs. In this study, this herb was hypothesized to help to ameliorate kidney disease in diabetes mellitus (DM).

Plant derived immunostimulants are a promising alternative to chemotherapeutics and also perhaps vaccines. In the present study, we examined the immunostimulating properties of aqueous leaf extract of Phyllanthus niruri, an Indian traditional medicinal herb, on neutrophil activation and antibody response of Oreochromis mossambicus (Peters).

In this study the potential use of an aqueous two phase system (ATPS) for the extraction of two lignans from Phyllanthus Niruri L. was evaluated and optimized using response surface methodology (RSM). Their anti-cancer potential against human lung cancer cell line A549, hepatic cancer cell line SMMC-7721, gastric cancer cell line MGC-803 were also evaluated respectively.

Phyllanthus niruri is a traditional shrub of the genus Phyllanthaceae with long-standing Ayurvedic, Chinese and Malay ethnomedical records. Preliminary studies from cell and animal model have provided valuable scientific evidence for its use.

Breast cancer is one of the most commonly diagnosed cancers and the leading causes of cancer death in women worldwide. Endophytic fungi becomes anticancer metabolite sources which alternatively in plants.

The antibacterial and antifungal activities of chloroform, ethanol, acetone and aqueous extracts of Pongamia glabra and Phyllanthus niruri leaves were screened. In antibacterial activity assay followed by standard disc diffusion method against Escherichia coli, Staphylococcus aureus, Micrococcus luteus and Enterobacter aerogens.

The in-vitro and in-vivo antifungal activities of saponin extracted from Phyllanthus niruri were investigated. The proximate composition of the plant determined using the methods of the Association of Official Analytical Chemists showed that the moisture, dry matter, crude protein, crude fibre, total ash and fat were available in 1.34 g, 98.66 g, 12.33 g 18.45 g, 7.36 g and 2.54 g/100 g respectively.

Introduction: Phyllanthus niruri is a traditional shrub of the genus Phyllan-thaceae with long-standing Ayurvedic, Chinese and Malay ethnomedical records. Preliminary studies from cell and animal model have provided valuable scientific evidence for its use.

Characterization and quantification of secondary metabolites and their bioactivity studies are essential to increase the knowledge on plants with traditional medicinal uses towards efficient and safe utilization.

Background: The medicinal plants signify a massive basin of potential phytoconstituents that could be valuable as a substitute to allopathic drugs or considered as an analogue in drug development. Phyllanthus niruri L. (Euphorbiaceae) is generally used in traditional medicine to treat ulcer and inflammation. In this project we investigated the methanolic extract of leaves of Phyllanthus niruri for anti-inflammatory and anti-ulcer activity.

P. niruri has been reported to possess antidiabetic and kidney protective effects. In the present study, the phytochemical constituents and in vitro antioxidant activity of P. niruri leaf aqueous extract were investigated together with its effect on oxidative stress and antioxidant enzymes levels in diabetic rat kidney.

In endemic areas where malaria is prevalent, medicinal plants are often used to treat malaria. This study was conducted to evaluate the in vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of meniran (Phyllanthus niruri L.) herb traditionally used to treat malaria in Indonesia.

This review discusses the medicinal plant Phyllanthus niruri Linn. (Euphorbiaceae), its wide variety of phytochemicals and their pharmacological properties. The active phytochemicals, flavonoids, alkaloids, terpenoids, lignans, polyphenols, tannins, coumarins and saponins, have been identified from various parts of P. niruri.

Herbal-derived medications are an important resource in eliminating serious diseases in developing countries. About 60–85% of the world’s inhabitants depend on traditional medicine for the treatment of common diseases.

Phyllanthus niruri (Euphorbiaceae) is reputed globally for its versatile application in traditional medicine of many Asian, African, and South American countries. In many preclinical and clinical studies, extracts of P. niruri have been associated with many beneficial pharmacological and therapeutic effects.

Postinfectious irritable bowel syndrome (PI-IBS) is a common disorder wherein symptoms of IBS begin after an episode of acute gastroenteritis. Published studies have reported incidence of PI-IBS that ranged between 5% and 32%. Its high prevalence and the considerable effects on quality of life make PI-IBS a disease with high social cost.

Liver diseases are commonly caused by viral infections, drug overdose, reactions to prescribed drugs and medications, prolonged or excessive exposure to environmental toxins, and long term effects of alcohol consumption.

Extracts of Phyllanthus niruri L., collected from three different areas in the Congo (Kisantu, Kimwenza and University of Kinshasa), used for malaria treatment were tested in vitro in order to evaluate their antiplasmodial properties.

It is well known that plant species synthesize and accumulate various secondary metabolites belonging to different phytochemical groups. In intact plants, the formation of these metabolites is regulated in a coordinated fashion. Differentiation of plant cells or tissues during development is implied in this process.

The increasing burden of malaria has contributed significantly to poverty, decreased productivity and slow economic growth in malaria endemic regions. In 2010 alone, an estimated 655 000 cases of malaria-associated deaths were recorded, especially in very young African children.

The potential of water extracts of the Amazon medicinal plant Chancapiedra (Phyllanthus niruri L.) from Ecuador and Peru for antimicrobial activity against Helicobacter pylori and different strains of lactic acid bacteria such as Lactobacillus acidophilus, Lactobacillus casei and Lactobacillus plantarum was investigated.

Reactive oxygen species (ROS) are generated spontaneously in cells during metabolism and are implicated in the aeitology of different degenerative diseases, such as heart diseases, stroke, rheumatoid arthritis, diabetes and cancer.

Nimesulide (NIM), an atypical non-steroidal anti-inflammatory drug (NSAID) is also used as analgesic. In the present study, we evaluated its effect on the prooxidant-antioxidant system of liver and the hepatoprotective potential of aqueous extract of the herb Phyllanthus niruri (PN) on NIM-induced oxidative stress in vivo using a murine model, by determining the activities of hepatic anti-oxidant enzymes superoxide dismutase (SOD) and catalase (CAT), levels of reduced glutathione (GSH) and lipid peroxidation (expressed as malonaldialdehyde, MDA).

Herbal products have been used since the dawn of civilization on the earth to maintain human health and to get the remedies from various diseases by the vast majority of the world’s population. Among these herbs, Phyllanthus niruri, has been widely used for the treatment of jaundice and other hepatic disorders.

Present study was conducted to evaluate the role of a protein fraction (PI, protein isolate) of the herb, Phyllanthus niruri (P. niruri) against nimesulide-induced oxidative stress in vivo using a murine model.

Free radicals, from both endogenous and exogenous sources, are implicated in the etiology of several degenerative diseases, such as coronary artery diseases, stroke, rheumatoid arthritis, diabetes and cancer.

The aim of this study was to investigate the hepatoprotective action of the protein fraction of Phyllanthus niruri against acetaminophen (APAP) hepatotoxicity. The partially purified protein fraction of P. niruri was injected intraperitoneally in mice either prior to (preventive) or after the induction of toxicity (curative).

Phyllanthus niruri Linn. (Euphorbiaceae) is used as folk medicine in South America to treat excess uric acid. Our initial study showed that the methanol extract of Phyllanthus niruri and its lignans were able to reverse the plasma uric acid of hyperuricemic animals.

The use of plants to heal or combat illness is as old as mankind. Since age long, plants have remained the basis for the development of modem drugs for human health. Medicinal plants are considerably useful and economically essential.

Chemoprevention is an important strategy to control the process of carcinogenesis. The potential of using medicinal herbs as cancer chemopreventive nutraceuticals and functional food is promising. Thus, there is a need for exploring drugs/agents which act as chemopreventive agents.

The ethanolic, dichloromethane and lyophilized aqueous extracts of Cassia occidentalis root bark, Morinda morindoides leaves and whole plants of Phyllanthus niruri were evaluated for their antimalarial activity in vivo, in 4-day, suppressive assays against Plasmodium berghei ANKA in mice.

In spite of considerable efforts to identify effective treatments for urolithiasis, this is a goal yet to be achieved. This review summarizes experimental and clinical data evaluating the effect of the plant Phyllanthus niruri, a plant with worldwide distribution, as a potential agent to prevent and/or to treat urolithiasis.

A preclinical study was performed to determine if the extract from Phyllanthus niruri (PN) plays a protective role against liver cirrhosis induced by thioacetamide (TAA) in rats. Initially, acute toxicity was tested and the results showed that the extract was benign when applied to healthy rats.

Phyllanthus niruri Linn has been used in Ayurvedic medicine for over 2,000 years and has been used in wide number of traditional ailments such as jaundice, gonorrhea, frequent menstruation, and diabetes and topically as a poultice for skin ulcers, sores, swelling, and itchness.

One new lignan, nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L. The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis.

Nirtetralin B, a new lignan first reported by our team, is isolated from Phyllanthus niruri L. This plant has long been used in folk medicine for liver protection and antihepatitis B in many Asian countries.

Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes.

The antidiabetic, hypolipidemic, and antioxidant properties of Phyllanthus niruri (L) (Euphorbiaceae) were compared in normal, insulin-dependent diabetes mellitus (IDDM), and non–insulin-dependent diabetes mellitus (NIDDM) animals through evaluating the effects on carbohydrate and lipid metabolism and antioxidant activities.

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to defective insulin action, insulin secretion or both.

The effects of methanol extract of aerial parts of Phyllanthus niruri L. (Euphorbiaceae), an antidiabetic herb, on glucose absorption and storage in diabetes were studied to elucidate the mechanisms of blood glucose lowering and glycemic control in diabetes.

Mosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. Recently, transmission has strongly increased in urban and semiurban areas, becoming a major international public health concern.

Phyllanthus niruri Linn. (Euphorbiaceae) is used as folk medicine in South America to treat excess uric acid. Our initial study showed that the methanol extract of Phyllanthus niruri and its lignans were able to reverse the plasma uric acid of hyperuricemic animals.