UP
DEPRESSIVE DISORDERS - MOOD DISORDERS - SUPPRESSED IMMUNE SYSTEM - MICROBIAL INFECTIONS - INFLAMMATION
MoodMedix is a combination of two extracts: Samento, produced from Uncaria tomentosa, and Avea, produced from Curcuma longa, commonly known as turmeric; both perennial plants from South America. Samento is made from the Uncaria tomentosa chemotype that does not contain Tetracyclic Oxindole Alkaloids (TOAs), a group of chemical antagonists that act upon the central nervous system and can greatly inhibit the positive effect of the Pentacyclic Oxindole Alkaloids (POAs). The POAs primarily affect the immune cells responsible for nonspecific and cellular immunity and demonstrate powerful immune system modulating properties. Avea is reported to be very effective in treating inflammation, digestive disorders and liver problems, skin diseases, wound healing, depression and other mood disorders. The proprietary blend of Samento and Avea found in MoodMedix has been shown to provide stronger effects than simply combining the products Samento and Avea.
ANTIBACTERIAL
ANTICANCEROUS
ANTIDEPRESSANT
ANTIFUNGAL
ANTI-HYPERTENSIVE
ANTILEUKEMIC
ANTIOXIDANT
ANTIPARASITIC
ANTIVIRAL
Moraes,R. C., Carvalho, A. R., Lana, A. J. D., Kaiser, S., Pippi, B., Fuentefria, A.M., & Ortega, G. G. (2017). In vitro synergism of a water insoluble fraction of Uncaria tomentosa combined with fluconazole and terbinafine against resistant non-Candida albicans isolates. Pharmaceutical biology,55(1), 406-415. Full Article
Moraes,R. C., Dalla Lana, A. J., Kaiser, S., Carvalho, A. R., de Oliveira, L. F. S., Fuentefria, A. M., & Ortega, G. G. (2015). Antifungal activity of Uncaria tomentosa (Willd.) DC against resistant non-albicans Candida isolates. Industrial Crops and Products,69, 7-14. Full Article
Montserrat-dela Paz, S., Fernandez-Arche, A., de la Puerta, R., Quilez, A. M., Muriana, F.J., Garcia-Gimenez, M. D., & Bermudez, B. (2016). Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine, 23(2), 141-148. Full Article
Rojas-Duran,R., González-Aspajo, G., Ruiz-Martel, C., Bourdy, G., Doroteo-Ortega, V. H.,Alban-Castillo, J., ... & Deharo, E. (2012). Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of Ethnopharmacology, 143(3),801-804. Full Article
Gonçalves,C., Dinis, T., & Batista, M. T. (2005). Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry, 66(1), 89-98. Full Article
Allen-Hall,L., Cano, P., Arnason, J. T., Rojas, R., Lock, O., & Lafrenie, R. M.(2007). Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1β and TNF-α. Journal of ethnopharmacology, 109(2), 312-317. Full Article
Aguilar, J. L., Rojas, P.,Marcelo, A., Plaza, A., Bauer, R., Reininger, E., ... & Merfort, I. (2002). Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae). Journal of Ethnopharmacology, 81(2), 271-276. Full Article
Sandoval, M., Okuhama, N. N.,Zhang, X. J., Condezo, L. A., Lao, J., Angeles, F. M., ... & Miller, M. J.S. (2002). Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine, 9(4),325-337. Full Article
Azevedo,B. C., Morel, L. J. F., Carmona, F., Cunha, T. M., Contini, S. H. T., Delprete, P. G., ... & Borges, M. C. (2018). Aqueous extracts from Uncaria tomentosa (Willd. ex Schult.) DC. reduce bronchial hyperresponsiveness and inflammation in a murine model of asthma. Journal of ethnopharmacology, 218, 76-89. Full Article
Kang,T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ...& Watanabe, H. (2002). Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte. European journal of pharmacology, 444(1-2), 39-45. Full Article
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