NUTRA-BRT

ANTIMICROBIAL

ANTIVIRAL

ANTIFUNGAL

ANTI-INFLAMMATORY

ANTIOXIDANT

IMMUNOMODULATORY

DETOXIFYING

RESPIRATORY-SUPPORTIVE

LYMPHATIC-STIMULATING

GUT-BALANCING

ADAPTOGENIC

Malaria

Roumy, V., Garcia-Pizango, G., Gutierrez-Choquevilca, A. L., Ruiz, L., Jullian, V., Winterton, P., ... & Valentin, A. (2007). Amazonian plants from Peru used by Quechua and Mestizo to treat malaria with evaluation of their activity. Journal of Ethnopharmacology, 112(3), 482-489. Full Article

Kvist, L. P., Christensen, S. B., Rasmussen, H. B., Mejia, K., & Gonzalez, A. (2006). Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis. Journal of Ethnopharmacology, 106(3), 390-402. Full Article

Acne

Chomnawang, M. T., Surassmo, S., Nukoolkarn, V.S., & Gritsanapan, W. (2005). Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. Journal of Ethnopharmacology, 101(1-3), 330-333. Full Article

Anaphylactic Reaction

Han, E. H., Park, J. H., Kim, J. Y., & Jeong, H. G. (2009). Houttuynia cordata water extract suppresses anaphylactic reaction and IgE-mediated allergic response by inhibiting multiple steps of FcεRI signaling in mast cells. Food and chemical toxicology, 47(7), 1659-1666. Full Article

Li, G. Z., Chai, O. H., Lee, M. S., Han, E. H.,Kim, H. T., & Song, C. H. (2005). Inhibitory effects of Houttuynia cordata water extracts on anaphylactic reaction and mast cell activation. Biological and Pharmaceutical Bulletin, 28(10), 1864-1868. Full Article

Alzheimer’s disease

Huh, E., Kim, H. G., Park, H., Kang, M. S., Lee,B., & Oh, M. S. (2014). Houttuynia cordata improves cognitive deficits in cholinergic dysfunction Alzheimer’s disease-like models. Biomolecules& Therapeutics, 22(3), 176. Full Article

Cancer

Kumnerdkhonkaen, P., Saenglee, S.,Asgar, M. A., Senawong, G., Khongsukwiwat, K., & Senawong, T. (2018). Antiproliferative activities and phenolic acid content of water and ethanolic extracts of the powdered formula of Houttuynia cordata Thunb. fermented broth and Phyllanthus emblica Linn. fruit. BMC complementary and alternative medicine, 18(1), 130. Full Article

Lai, K. C., Chiu, Y. J., Tang, Y. J.,Lin, K. L., Chiang, J. H., Jiang, Y. L., ... & Yang, J. S. (2010). Houttuynia cordata Thunb extract inhibits cell growth and induces apoptosis in human primary colorectal cancer cells. Anticancer research, 30(9), 3549-3556. Full Article

Colon Cancer

Tang, Y. J., Yang, J. S., Lin, C. F., Shyu, W. C., Tsuzuki, M., Lu, C. C., ... & Lai, K. C. (2009). Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells. Oncology reports, 22(5), 1051-1056. Full Article

Dengue Virus

Chiow, K. H., Phoon, M. C., Putti, T.,Tan, B. K., & Chow, V. T. (2016). Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection. Asian-Pacific journal of tropical medicine, 9(1), 1-7. Full Article

Leardkamolkarn, V., Sirigulpanit, W., Phurimsak, C., Kumkate, S., Himakoun, L., & Sripanidkulchai, B. (2012). The inhibitory actions of houttuynia cordata aqueous extract on dengue virus and dengue‐infected cells. Journal of food biochemistry, 36(1), 86-92. Full Article

Diabetes

Kumar, M., Prasad, S. K.,Krishnamurthy, S., & Hemalatha, S. (2014). Antihyperglycemic activity of Houttuynia cordata Thunb. instreptozotocin-induced diabetic rats. Advances in pharmacological sciences, 2014. Full Article

Leukemia

Chang, J. S., Chiang, L. C., Chen, C.C., Liu, L. T., Wang, K. C., & Lin, C. C. (2001). Antileukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb. The American journal of Chinese medicine, 29(02),303-312. Full Article

Lung Cancer

Chen, Y. F., Yang, J. S., Chang, W.S., Tsai, S. C., Peng, S. F., & Zhou, Y. R. (2013). Houttuynia cordata Thunb extract modulates G 0/G 1 arrest andFas/CD95-mediated death receptor apoptotic cell death in human lung cancer A549 cells. Journal of biomedical science, 20(1), 18. Full Article

Lung Injury

Lu, Y., Jiang, Y., Ling, L., Zhang, Y., Li, H., & Chen, D. (2018). Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities. Actapharmaceutica sinica B, 8(2), 218-227. Full Article

Herpes Simplex Virus (HSV)        

Hung, P. Y., Ho, B. C., Lee, S. Y.,Chang, S. Y., Kao, C. L., Lee, S. S., & Lee, C. N. (2015). Houttuynia cordata targets the beginning stage of herpes simplex virus infection. PloS one, 10(2), e0115475. Full Article

Chen, X., Wang, Z., Yang, Z., Wang,J., Xu, Y., Tan, R. X., & Li, E. (2011). Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation. Antiviral research,92(2), 341-345. Full Article

Chiang, L. C., Chang, J. S., Chen, C.C., Ng, L. T., & Lin, C. C. (2003). Anti-Herpes simplex virus activity of Bidens pilosa and Houttuynia cordata. The American journal of Chinese medicine, 31(03), 355-362. Full Article

Influenza

Zhu, H., Lu, X.,Ling, L., Li, H., Ou, Y., Shi, X., ... & Chen, D. (2018). Houttuynia cordata polysaccharides ameliorate pneumonia severity and intestinal injury in mice with influenza virus infection. Journal of ethnopharmacology, 218, 90-99. Full Article

Rapid pulmonary fibrosis (RPF)

Du, S., Li, H., Cui, Y., Yang, L., Wu, J., Huang, H., ... & Chen, D. (2012). Houttuynia cordata inhibits lipopolysaccharide-induced rapid pulmonary fibrosis by up-regulating IFN-γ and inhibiting the TGF-β1/Smad pathway. International immunopharmacology, 13(3), 331-340. Full Article

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Male Enhancement

Schmeda-Hirschmann, G., Burgos-Edwards, A., Theoduloz, C., Jiménez-Aspee, F., & Vargas-Arana, G. (2019). Male sexual enhancers from the Peruvian Amazon. Journal of ethnopharmacology, 229,167-179. Full Article

Anticestodal activity

Yadav, A. K. (2011). Anticestodal activity of Houttuynia cordata leaf extract against Hymenolepis diminuta in experimentally infected rats. Journal of Parasitic Diseases, 35(2), 190-194. Full Article

Anti-inflammatory

Shingnaisui, K., Dey, T., Manna, P., & Kalita, J. (2018). Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A Review. Journal of ethnopharmacology. Full Article

Li,W., Fan, T., Zhang, Y., Fan, T., Zhou, P., Niu, X., & He, L. (2013). Houttuynia cordata Thunb. Volatile Oil Exhibited Anti‐inflammatory Effects In Vivo and Inhibited Nitric Oxide and Tumor Necrosis Factor‐α Production in LPS‐stimulated Mouse PeritonealMacrophages In Vitro. Phytotherapy Research, 27(11), 1629-1639. Full Article

Lee,H. J., Seo, H. S., Kim, G. J., Jeon, C. Y., Park, J. H., Jang, B. H., ... &Ko, S. G. (2013). Houttuynia cordata Thunb inhibits the production of pro‑inflammatory cytokines through inhibition of the NFκB signaling pathway in HMC‑1 human mast cells. Molecular medicine reports, 8(3), 731-736. Full Article

Kim,D., Park, D., Kyung, J., Yang, Y. H., Choi, E. K., Lee, Y. B., ... & Kim,Y. B. (2012). Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model. Laboratory animal research, 28(2), 137-140. Full Article

Li,W., Zhou, P., Zhang, Y., & He, L. (2011). Houttuynia cordata, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Journal of ethnopharmacology, 133(2), 922-927. Full Article

Shin,S., Joo, S. S., Jeon, J. H., Park, D., Jang, M. J., Kim, T. O., ... & Kim,Y. B. (2010). Anti-inflammatory effectsof a Houttuynia cordata supercritical extract. Journal of veterinary science, 11(3), 273-275. Full Article

Kim,I. S., Kim, J. H., Kim, J. S., Yun, C. Y., Kim, D. H., & Lee, J. S. (2007).The inhibitory effect of Houttuynia cordata extract on stem cell factor-induced HMC-1 cell migration. Journal of ethnopharmacology, 112(1), 90-95. Full Article

Lu,H. M., Liang, Y. Z., Yi, L. Z., & Wu, X. J. (2006). Anti-inflammatory effect of Houttuynia cordata injection. Journal of Ethnopharmacology, 104(1-2), 245-249. Full Article

Antibacterial

Li,J., Rehman, M. U., Zhang, H., Iqbal, M. K., Mehmood, K., Huang, S., & Nabi, F. (2017). Antibacterial effect of the water extract of Houttuynia cordata water extract against multi-drug resistant Escherichia coli. Southeast Asian Journal of Tropical Medicine and Public Health, 48(6), 1260-1266. Full Article

Sekita, Y., Murakami, K., Yumoto, H., Mizuguchi, H., Amoh, T., Ogino, S., ... & Kashiwada, Y. (2016). Anti-bacterial and anti-inflammatory effects of ethanol extract from Houttuynia cordata poultice. Bioscience, biotechnology, and biochemistry, 80(6), 1205-1213. Full Article

Li,W., Zhou, P., Zhang, Y., & He, L. (2011). Houttuynia cordata, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Journal of Ethnopharmacology, 133(2),922-927. Full Article

Kim,G. S., Kim, D. H., Lim, J. J., Lee, J. J., Han, D. Y., Lee, W. M., ... &Lee, H. J. (2008). Biological and antibacterial activities of the natural herb Houttuynia cordata water extract against the intracellular bacterial pathogen salmonella within the RAW 264.7 macrophage. Biological and Pharmaceutical Bulletin, 31(11), 2012-2017. Full Article

Antioxidant

Kang, H., & Koppula, S. (2014). Hepatoprotective effect of Houttuynia cordata thunb extract against carbon tetrachloride-induced hepatic damage in mice. Indian journal of pharmaceutical sciences, 76(4),267. Full Article

Tian, L., Shi, X., Yu, L., Zhu, J., Ma, R., & Yang, X. (2012). Chemical composition and hepatoprotective effects of polyphenol-rich extract from Houttuynia cordata tea. Journal of agricultural and food chemistry, 60(18), 4641-4648. Full Article

Tian,L., Zhao, Y., Guo, C., & Yang, X. (2011). A comparative study on the antioxidant activities of an acidic polysaccharide and various solvent extracts derived from herbal Houttuynia cordata. Carbohydrate Polymers,83(2), 537-544. Full Article

Nuengchamnong, N., Krittasilp, K., & Ingkaninan, K. (2009). Rapid screening and identification of antioxidants in aqueous extracts of Houttuynia cordata using LC–ESI–MS coupled with DPPH assay. Food Chemistry, 117(4), 750-756. Full Article

Chen, Y. Y., LIU, T. F., Chen, C. M., Chao, P. Y.,& Chang, T. J. (2003). A study of the antioxidative and antimutagenic effects of Houttuynia cordata Thunb. using an oxidized frying oil-fed model. Journal of nutritional science and vitaminology, 49(5), 327-333. Full Article

Anti-Obesity

Miyata, M., Koyama, T., & Yazawa, K. (2010). Water extract of Houttuynia cordata Thunb. leaves exerts anti-obesity effects by inhibiting fatty acid and glycerol absorption. Journal of nutritional science and vitaminology, 56(2), 150-156. Full Article

Hepatoprotector

Chen, W. T., Yang, C. L., &Yin, M. C. (2014). Protective effects from Houttuynia cordata aqueous extract against acetaminophen-induced liver injury. Biomedicine, 4(1). Full Article

Immunomodulating

Lee, J. S., Kim, I. S., Kim, J. H., Kim, J. S., Kim,D. H., & Yun, C. Y. (2008). Suppressive effects of Houttuynia cordata Thunb (Saururaceae) extract on Th2 immune response. Journal of ethnopharmacology, 117(1), 34-40. Full Article

Lau, K. M., Lee, K. M., Koon, C. M., Cheung, C. S.F., Lau, C. P., Ho, H. M., ... & Tsui, S. K. W. (2008). Immunomodulatory and anti-SARS activities of Houttuynia cordata. Journal of Ethnopharmacology, 118(1), 79-85. Full Article

Various Conditions

Sekita, Y.,Murakami, K., Yumoto, H., Amoh, T., Fujiwara, N.,Ogata, S., ... & Kashiwada, Y. (2016). Preventive effects of Houttuynia cordata extract for oral infectious diseases. BioMed Research International, 2016. Full Article

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Put 2 to 60 drops in 4 oz (120 mL) of water and wait one minute before drinking. Start with 2 drops (30 min before meals) increasing by 2 drops with each dose up to 60 drops, 2 times a day or as directed by physician