PINELLA

Nonalcoholic fatty liver disease (NAFLD) is defined as a spectrum of chronic liver disorders caused by irregular accumulation of fat in liver tissue which results in steatosis, inflammation, and in severe cases, cirrhosis. NAFLD is categorized into two main types including simple steatosis (fatty liver) and nonalcoholic steatohepatitis.

Aniseed (Pimpinella anisum L., Apiaceae) is a medicinal and aromatic plant widely cultivated in the Mediterranean area and used in foodstuffs, as ingredient of famous liqueurs, confectionery and bakery products. Its essential oil is one of the most selled on the market and used on an industrial level

Pimpinella anisum L. (family Apiaceae) is widely used for curing variety of ailments. The objective of this study was to evaluate the antimicrobial activity and chemical composition of chloroform and ethanol extracts from the seed of Pimpinella anisum against standard microorganism.

Chemical composition and antioxidant activity of four aniseed populations (Egyptian, Serbian, Tunisian and Turkish) were investigated during three developmental stages. The highest oil yield was achieved at full maturity in all aniseed accessions ranged from 11.93% (Serbia) to 13.80% (Tunisia). Fatty acid profile of aniseed oil was characterized by high proportions of palmitic (4.90–57.18%) and petroselinic (10.48–46.60%) acids which had an antagonist evolution during maturation.

Investigations were conducted to evaluate the antifungal activity of anise and cumin essential oils on mycelia growth of 90 isolates of fungi. The agar-well diffusion method was used to evaluate fungal growth inhibition at a concentration of 100%.

The majority of the currently used cosmetics and drugs are natural products-based compounds or their derivatives. This could add weight to the argument that natural based products are inherently better tolerated in the body than synthetic chemicals and have higher chance to be approved as drugs.

To study adverse side effects produced by the administration of PINELLA on body weight and different body systems.

Because Pimpinella anisum is highly used in the folk medicine, a study of its physiological properties was deemed necessary and informative. At present, the mechanisms involved in the relaxant action induced by the extract of Pimpinella anisum are poorly understood. This work aimed to investigate the possible mechanism(s) underlying the relaxant action of the hidroalcoholic extract of Pimpinella anisum on rat anococcygeus smooth muscle.

The essential oil obtained by hydrodistillation from the fruits of Pimpinella anisum L. (green anise) and Foeniculum vulgare Miller (fennel) were analyzed by GC and GC/MS and physicochemical properties.

In the present study the relaxant effects of essential oil, aqueous and ethanol extracts of this plant in comparison with both saline and theophylline were studied by a more standard method. In addition the anticholinergic effect of essential oil of P. anisum in comparison with atropine was also studied.

The present study was conducted to isolate the most important bioactive compound from Pimpinella anisum L. fruit oil.

Medicinal plants synthesize a vast array of secondary metabolites that are important for human life.

Pimpinella anisum is a member of the Umbelliferae and is found in the North-Eastern Anatolia. In Turkish folk medicine, Pimpinella species have been used as analgesic, antiinflammatory, appetizing, hypnotic, expectorant, antibacterial and hepatoprotective agents and to increase milk secretion. The seeds of P. anisum contain 1.5-6% essential oil, 10-20% fixed oil and 18% protein.

The auricular edema is achieved by applying 12-0- Tetradecanoil Forbol-13 Acetate (TPA), one of the components responsible for the irritating action of croton oil, into the auditory pavilion of the mouse.

Increasing attentions have been paid on the application of essential oils and plant extracts for control of postharvest pathogens due to their natural origin and less appearance of resistance in fungi pathogens.

In this study, lipid peroxidation (marker of oxidative stress) inhibitory effect and antidiabetic activity of various fractions of aniseed (Pimpinella anisum L.) obtained by sequential fractionation of methanolic extract using hexane, benzene, ethyl acetate, n-butanol and water were evaluated using in vitro methods and model systems.

We studied a green synthesis route to produce AgNPs by using an aqueous extract of Pimpinella anisum seeds (3 mM). Their antimicrobial activity and cytotoxicity on human neonatal skin stromal cells (hSSCs) and colon cancer cells (HT115) were assessed.

Pimpinella anisum (anise), belonging to Umbelliferae family, is an aromatic plant which has been used In Iranian traditional medicine (especially its fruits) as carminative, aromatic, disinfectant, and galactagogue. Because the wide traditional usage of Pimpinella anisum for treatment of diseases, in this review published scientific reports about the composition and pharmacological properties of this plant were collected with electronic literature search of GoogleScholar, PubMed, Sciencedirect, Scopus, and SID from 1970 to 2011.

The antiviral activity of the essential oils of Foeniculum vulgare Mill. and Pimpinella anisum L. has been tested against PVX (potato virus X), TMV (tobacco mosaic virus) and TRSV (tobacco ring spot virus) on the hypersensitive host Chenopodium amaranticolor.

Three antiviral and immunostimulating substances (LC1, LC2 and LC3) were isolated from a hot water extract of seeds of Pimpinella anisum by combination of anion-exchange, gel filtration and hydrophobic interaction column chromatographies. Chemical and spectroscopic analyses revealed them to be lignin-carbohydrate-protein complexes.

The antioxidant activity and essential oil content of plants may vary considerably with respect to environmental conditions, especially nutrient availability. Among micronutrients, zinc (Zn) is needed by plants in only small amounts but is crucial to plant development. This study aimed to evaluate the effects of Zn fertilization on the antioxidant activity, polyphenolic contents and essential oil composition of Pimpinella anisum fruit.

In this study, antioxidant and antimicrobial activities of water and ethanol extracts of anise (Pimpinella anisum L.) seed (PAS) were investigated. The antioxidant properties of both extracts of PAS were evaluated using different antioxidant tests, including reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities.

Recently, interest in plant-derived food additives has grown, mainly because of toxic effects associated with synthetic antioxidants. In the present study, the chemical composition and antioxidant properties of essential oil and oleoresins of the seeds of anise (Pimpinella anisum) was investigated.

Protective effects of different extracts and essential oil from Pimpinella anisum L. seeds were examined against carbon tetrachloride (CCl4)-induced toxicity. The parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. In the in vitro model of this study, markers such as cell viability, cellular reduced and oxidized glutathione and lipid peroxidation in HepG2 cells were evaluated.

Antifungal activities of fluid extract and essential oil obtained from anise fruits Pimpinella anisum L. (Apiaceae) were tested in vitro on clinical isolates of seven species of yeasts and four species of dermatophytes.

Medicinal plants synthesize a vast array of secondary metabolites that are important for human life. For medicinal purpose, antimicrobial activity of substances derived from plant extracts has been recognized for many years. Pimpinella anisum L. (Apiaceae) and Illicium verum Hook. f. (Illiciaceae) plant species, have been used for treatment of infectious diseases in Iranian traditional medicine.

Previously, we reported the antifungal properties of some essential oils of angiosperms.

This study investigates anticonvulsant effects of an essential oil of the fruits of Pimpinella anisum (Umbelliferae), a folkloric remedy in the Iranian traditional medicine, against seizures induced by pentylenetetrazole (PTZ) or maximal electroshock (MES) in male mice.

Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil.

The antibacterial activities of the aqueous, 50% (v/v) methanol,acetone and petroleum ether extracts of Pimpinella anisum (L) fruits were studied.

We report in this study the chemical composition and antibacterial activities of the seed’s essential oils of Pimpinella anisum L. collected from Morocco and Yemen.

Essential oils (EOs) and methanol extracts obtained from aerial parts of Thymus vulgaris and Pimpinella anisum seeds were evaluated for their single and combined antibacterial activities against nine Gram-positive and Gram-negative pathogenic bacteria: Staphylococcus aureus, Bacillus cereus, Escherichia coli, Proteus vulgaris, Proteus mirabilis, Salmonella typhi, Salmonella typhimurium, Klebsiella pneumoniae and Pseudomonas aeruginosa.

Increasing microbial resistance to chemical antibiotics and their probabilistic side effects cause popularity of medicinal plants, so there is an instantaneous and steady need for novel antimicrobial compounds from plants.