NUTRA-BBS

EXPECTORANT

PURGATIVE

ASTRINGENT

ANTIOXIDANT

ANTI-INFLAMMATORY

ANTIMICROBIAL

DETOXIFYING

RESPIRATORY-SUPPORTIVE

DIGESTIVE-SUPPORTIVE

IMMUNE-MODULATING

SKIN-REPARATIVE

MUCOLYTIC

TONIC

ANTISEPTIC

LYMPHATIC-SUPPORTIVE

Atopic dermatitis

Wang, Q., Gao, S., Wu, G. Z., Yang, N., Zu, X. P.,Li, W. C., ... & Zhang, W. D. (2018). Total sesquiterpene lactones isolated from Inula helenium L. attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice. Phytomedicine. Full Article

Cancer

Zhang, B., Zeng, J., Yan, Y., Yang, B., Huang, M.,Wang, L., ... & Lin, N. (2018). Ethyl acetate extract from Inula helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway. Molecular medicinereports, 17(4), 5440-5448. Full Article

Koc, K., Ozdemir, O., Ozdemir, A., Dogru, U.,& Turkez, H. (2018). Antioxidant and anticancer activities of extract of Inula helenium (L.) in human U-87 MG glioblastoma cell line. Journal of cancer research and therapeutics, 14(3),658. Full Article

Malaria

Christy, A. O., Mojisola, C. O. C., Taiwo, E. O., & Ola, O. O. (2016). The antimalaria effect of Momordica charantia L. and Mirabilis jalapa leaf extracts using animal model. Journal of Medicinal Plants Research, 10(24), 344-350. Full Article

Pancreatic cancer

Zhang, B., Zeng, J., Yan, Y., Yang, B., Huang, M.,Wang, L., ... & Lin, N. (2018). Ethyl acetate extract from Inula helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway. Molecular medicine reports, 17(4), 5440-5448. Full Article

Psychophysiological disorders

Sowndhararajan, K., Cho, H., Yu, B., Song, J.,& Kim, S. (2016). Effect of inhalation of essential oil from Inula helenium L. root on electroencephalographic (EEG) activity of the human brain. European Journal of Integrative Medicine, 8(4), 453-457. Full Article

Rheumatoid arthritis

Gao, S., Wang, Q., Tian, X. H., Li, H. L., Shen, Y. H., Xu, X. K., ... & Zhang, W. D. (2017). Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis. Journal of ethnopharmacology, 196, 39-46. Full Article

Various conditions

Zia-Ul-Haq, M., Riaz, M., & Feo, V. D. (2012). Ipomea hederacea Jacq.: a medicinal herb with promising health benefits. Molecules, 17(11), 13132-13145. Full Article

‍

Anti-tumor

Li, Y., Ni, Z. Y., Zhu, M. C.,Dong, M., Wang, S. M., Shi, Q. W., ... & Cong, B. (2012). Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica. Zeitschrift für Naturforschung C, 67(7-8), 375-380. Full Article

Dorn, D. C., Alexenizer, M., Hengstler, J. G., & Dorn, A. (2006). Tumor cell specific toxicity of Inula helenium extracts. Phytotherapy Research:An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 20(11), 970-980. Full Article

Adjunct to Chemotherapy

Seo, J. Y., Park, J., Kim, H. J., Lee,I. A., Lim, J. S., Lim, S. S., ... & Kim, J. S. (2009). Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes. Journal of medicinal food,12(5), 1038-1045. Full Article

Anti-inflammatory

Park, E. J., Kim, Y. M., Park, S. W.,Kim, H. J., Lee, J. H., Lee, D. U., & Chang, K. C. (2013). Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice. Food and chemical toxicology, 55, 386-395. Full Article

Antistressor

Zelenskaya, K. L., Povet’eva, T.N., Pashinskii, V. G., Fomina, T. N., Timina, E. A., & Perova, A. V.(2005). Stress-inducing effect of hypoxia of different origin and its correction with Inula Helenium L. tincture. Bulletin of experimental biology and medicine, 139(4), 414-417. Full Article

Antioxidant

Kumar, S., & Fathima, E. (2017). Mirabilis jalapa: Phytochemical screening and anti-stress activity of methanolic leaf extract. Journal of Pharmacognosy and Phytochemistry, 6(6),1502-1508. Full Article

Lee, S. G., & Kang, H. (2016). Anti-neuro inflammatory effects of ethanol extract of Inula helenium L (Compositae). Tropical Journal of Pharmaceutical Research, 15(3), 521-526. Full Article

Albayrak, S., Korkmaz Cinar, A. E.,Paksoy, M. Y., & Aksoy, A. (2015). An investigation on antioxidant and antimicrobial activities of four Inula helenium L. taxa. Iranian Journal of Science and Technology (Sciences),39(4), 473-483. Full Article

Wang, J., Zhao, Y. M., Zhang, B., & Guo, C. Y. (2015). Protective effect of total phenolic compounds from inula helenium on hydrogen peroxide-induced oxidative stress in sh-sy5y cells. Indian journal of pharmaceutical sciences, 77(2), 163. Full Article

Petkova, N., Vrancheva, R., Mihaylova, D., Ivanov, I., Pavlov, A., & Denev, P. (2015). Antioxidant activity and fructan content in root extracts from elecampane (Inula helenium L.). Journal of BioScience & Biotechnology,4(1). Full Article

Spiridon, I., Nechita, C., Niculaua, M., Silion, M., Armatu, A., Teacă, C. A., & Bodîrlău, R. (2013). Antioxidant and chemical properties of Inula helenium root extracts. Open Chemistry, 11(10), 1699-1709. Full Article

Seo, J. Y., Lim, S. S., Kim, J. R.,Lim, J. S., Ha, Y. R., Lee, I. A., ... & Kim, J. S. (2008). Nrf2‐mediated induction of detoxifying enzymes by alantolactone present in Inula helenium. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 22(11), 1500-1505. Full Article

Nesterova, I., Zelenskaia, K. L.,Vetoshkina, T. V., Aksinenko, S. G., Gorbacheva, A. V., & Gorbatykh, N. A.(2003). Mechanisms of antistressor activity of Inula helenium preparations. Eksperimental'naia i klinicheskaia farmakologiia, 66(4), 63-65. Full Article

Antibacterial

Khan, I., Khan, U.,Khan, W., Subhan, M., Nawaz, M. A., Pervez, S., ... & Ahmad, S. (2017). Antibacterial and antibiofilm potential of leaves extracts of Mirabilis jalapa L. and Ajuga bracteosa wall. against Pseudomonas aeruginosa. Pure and Applied Biology (PAB), 6(2), 605-613. Full Article

Stojanović-Radić, Z., Čomić, L., Radulović, N., Blagojević, P., Denić, M., Miltojević, A., ...& Mihajilov-Krstev, T. (2012). Antistaphylococcal activity of Inula helenium L. root essential oil: eudesmane sesquiterpene lactones induce cell membrane damage. European journal of clinical microbiology & infectious diseases, 31(6), 1015-1025. Full Article

O’shea, S., Lucey,B., & Cotter, L. (2009). In vitro activity of Inula helenium against clinical Staphylococcus aureus strains including MRSA. British journal of biomedical science, 66(4),186-189. Full Article

Antiproliferative

Konishi, T., Shimada, Y., Nagao, T., Okabe, H., & Konoshima, T. (2002). Antiproliferative sesquiterpene lactones from the roots of Inula helenium. Biological and Pharmaceutical Bulletin, 25(10), 1370-1372. Full Article

Antimicrobial

Akthar, J. (2016). An antioxidant and antimicrobial activities of Inula helenium. Technology, 2(3). Full Article

DIGUȚĂ,C., Cornea, C. P., IONIȚĂ, L., BRÎNDUȘE, E., FARCAȘ, N., Bobit, D., & Matei, F. (2014). Studies on antimicrobial activity of Inula helenium L Romanian cultivar. Romanian Biotechnological Letters, 19(5), 9699. Full Article

Deriu, A., Zanetti, S., Sechi, L. A., Marongiu, B., Piras, A., Porcedda, S., & Tuveri, E. (2008). Antimicrobial activity of Inula helenium L. essential oil against Gram-positive and Gram-negative bacteria and Candida spp. International Journal of Antimicrobial Agents, 31(6), 588-590. Full Article

Immunomodulating 

Grigore, A., Neagu, G., Dobre, N., Ionita, C., Ionita, L., & Bobit, D. (2016). Immunomodulatory potential of Inula Helenium L. Analele Stiintifice ale Universitatii" Al. I. Cuza" din Iasi, 62(2), 29. Full Article

Wound Healing

Butko, А. Y. (2013). Experimental studies of the wound-healing action of Inula helenium and Inula britannica thick extracts on the conventional injury model (phantom) in rats. Клінічна фармація, (17,№ 4), 34-37. Full Article

‍

Put 2 to 60 drops in 4 oz (120 mL) of water and wait one minute before drinking. Start with 2 drops (30 min before meals) increasing by 2 drops with each dose up to 60 drops, 2 times a day or as directed by physician