UP
FOR PROMTING HEALTHY CIRCULATION, FIBRINOLYTIC ACTIVITY, AND NORMAL BLOOD PRESSURE
Nattokinase is a naturally occurring enzyme derived from natto, a traditional Japanese food made from fermented soybeans. The fermentation process, which uses the bacterium Bacillus subtilis natto, results in the production of this potent enzyme. One of the most notable properties of nattokinase is its fibrinolytic activity—meaning it can help break down fibrin, a protein involved in blood clot formation. By supporting the body’s ability to maintain clear and unobstructed blood vessels, nattokinase helps to promote optimal blood flow and maintain healthy blood pressure levels. In addition to its cardiovascular benefits, nattokinase supports a healthy inflammatory response.
FIBRINOLYTIC
ANTITHROMBOTIC
CIRCULATORY SUPPORT
CARDIOVASCULAR SUPPORT
ANTI-INFLAMMATORY
ANTIHYPERTENSIVE
BLOOD-CLEANSING
CLOT-DISSOLVING
PLATELET-MODULATING
VASOPROTECTIVE
Weng, Y., Yao, J., Sparks, S., & Wang, K. Y. (2017). Nattokinase: An oral antithrombotic agent for the prevention of cardiovascular disease. International Journal of Molecular Sciences, 18(3), 523. Full Article
Zhang, F., Zhang, J., & Linhardt, R. J. (2015). Interactions between nattokinase and heparin/GAGs. Glycoconjugate Journal, 32(9), 695–702. Full Article
Li, X., Long, J., Gao, Q., Pan, M., Wang, J., Yang, F., & Zhang, Y. (2023). Nattokinase supplementation and cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled trials. Reviews in Cardiovascular Medicine, 24(8), 234. Full Article
Nara, N., Kurosawa, Y., Fuse-Hamaoka, S., Kuroiwa, M., Endo, T., Tanaka, R., Kime, R., & Hamaoka, T. (2023). A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study. Heliyon, 9, e17951. Full Article
Chen, H., McGowan, E. M., Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X., & Lin, Y. (2018). Nattokinase: A promising alternative in prevention and treatment of cardiovascular diseases. Biomarker Insights, 13, 1–8. Full Article
Jang, J.-Y., Kim, T.-S., Cai, J., Kim, J., Kim, Y., Shin, K., Kim, K. S., Park, S. K., Lee, S.-P., Choi, E.-K., Rhee, M. H., & Kim, Y.-B. (2013). Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation. Laboratory Animal Research, 29(4), 221–225. Full Article
Kurosawa, Y., Nirengi, S., Homma, T., Esaki, K., Ohta, M., Clark, J. F., & Hamaoka, T. (2015). A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Scientific Reports, 5, 11601. Full Article
Hsia, C.-H., Shen, M.-C., Lin, J.-S., Wen, Y.-K., Hwang, K.-L., Cham, T.-M., & Yang, N.-C. (2009). Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutrition Research, 29(3), 190–196. Full Article
Fujita, M., Ohnishi, K., Takaoka, S., Ogasawara, K., Fukuyama, R., & Nakamuta, H. (2011). Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats. Biological & Pharmaceutical Bulletin, 34(11), 1696–1701. Full Article
Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K.-C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., & Lee, J. H. (2008). Effects of nattokinase on blood pressure: A randomized, controlled trial. Hypertension Research, 31(8), 1583–1588. Full Article
Jensen, G. S., Lenninger, M., Ero, M. P., & Benson, K. F. (2016). Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: Results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial. Integrated Blood Pressure Control, 9, 95–104. Full Article
Gallelli, G., Di Mizio, G., Palleria, C., Siniscalchi, A., Rubino, P., Muraca, L., Cione, E., Salerno, M., De Sarro, G., & Gallelli, L. (2021). Data recorded in real life support the safety of nattokinase in patients with vascular diseases. Nutrients, 13(6), 2031. Full Article
Pais, E., Alexy, T., Holsworth, R. E., & Meiselman, H. J. (2006). Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clinical Hemorheology and Microcirculation, 35(1-2), 139–142.
Take one capsule one to two times daily (at least 30 min. before meals) with a full glass of water or as directed by your physician
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